課程資訊
課程名稱
 口腔黏膜病生理學
Diseases and Pathophysiology in Oral Mucosa 
開課學期
 110-2 
授課對象
 醫學院  口腔生物科學研究所  
授課教師
 郭瑋庭 
課號
 OraBio7316 
課程識別碼
 450 M3160 
班次
  
學分
 3.0 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期三5,6,7(12:20~15:10) 
上課地點
 口生所討論室 
備註
 總人數上限：20人
外系人數限制：10人 
  
課程簡介影片
 
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課程概述

This course is intended for further in-depth study of the physiology and pathology in the oral mucosa and related diseases. The students will study the disordered physiological processes that are associated with a disease or injury. 

課程目標
 The content of the course will focus on critical discussion of scientific papers in the field of oral mucosal pathophysiology. 
課程要求
 Undergraduate students over the fourth year and graduate students in medicine-and biology-related studies are encouraged to take the course. Also, it is strongly encouraged for the students to take the “Oral Structure and Function” course before taking this class. The course is offered as two credits per school term.  
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 Iconic and recent 5-year research and review articles in the oral pathophysiology field will be discussed in the classes. 
參考書目
  
評量方式
(僅供參考)
    
課程進度
週次
日期
單元主題
Week 1
 2/16  Introduction 
Week 2
 2/23  Congenital disease – Cleft lip and palate
Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. M. M. Muggenthaler, B. Chowdhury, S. N. Hasan, H. E. Cross, B. Mark, G. V. Harlalka, et al. PLoS Genet 2017 Vol. 13 Issue 1 Pages e1006470 
Week 3
 3/2  Bacteria-induced disease – Gingivitis
Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation. O. Chipashvili, D. R. Utter, J. K. Bedree, Y. Ma, F. Schulte, G. Mascarin, et al. Cell Host Microbe 2021 Vol. 29 Issue 11 Pages 1649-1662 e7 
Week 4
 3/9  Bacteria-induced disease – Gingivitis
Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis. T. Maekawa, J. L. Krauss, T. Abe, R. Jotwani, M. Triantafilou, K. Triantafilou, et al. Cell Host Microbe 2014 Vol. 15 Issue 6 Pages 768-78 
Week 5
 3/16  Bacteria-induced disease – Periodontitis
Gingival solitary chemosensory cells are immune sentinels for periodontitis. X. Zheng, M. Tizzano, K. Redding, J. He, X. Peng, P. Jiang, et al. Nat Commun 2019 Vol. 10 Issue 1 Pages 4496 
Week 6
 3/23  Bacteria-induced disease – Scarlet fever
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. S. Brouwer, T. C. Barnett, D. Ly, K. J. Kasper, D. M. P. De Oliveira, T. Rivera-Hernandez, et al. Nat Commun 2020 Vol. 11 Issue 1 Pages 5018 
Week 7
 3/30  Virus-induced disease – Herpes simplex
RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice. Z. Huang, S. Q. Wu, Y. Liang, X. Zhou, W. Chen, L. Li, et al. Cell Host Microbe 2015 Vol. 17 Issue 2 Pages 229-42 
Week 8
 4/6  Middle Exam Week 
Week 9
 4/13  Virus-induced disease – Herpes simplex
Herpes simplex virus suppresses necroptosis in human cells.
H. Guo, S. Omoto, P. A. Harris, J. N. Finger, J. Bertin, P. J. Gough, et al. Cell Host Microbe 2015 Vol. 17 Issue 2 Pages 243-51 
Week 10
 4/20  Virus-induced disease – Mumps
Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1. K. Briggs, L. Wang, K. Nagashima, J. Zengel, R. A. Tripp and B. He. J Virol 2020 Vol. 94 Issue 12 
Week 11
 4/27  Fungus-induced disease – Oral candidiasis
IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils. K. Trautwein-Weidner, A. Gladiator, S. Nur, P. Diethelm and S. LeibundGut-Landmann. Mucosal Immunol 2015 Vol. 8 Issue 2 Pages 221-31 
Week 12
 5/4  Fungus-induced disease – Oral candidiasis
IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis. H. R. Conti, V. M. Bruno, E. E. Childs, S. Daugherty, J. P. Hunter, B. G. Mengesha, et al. Cell Host Microbe 2016 Vol. 20 Issue 5 Pages 606-617 
Week 13
 5/11  Autoimmune disease – Sjögren syndrome
Salivary dysbiosis in Sjogren's syndrome and a commensal-mediated immunomodulatory effect of salivary gland epithelial cells. Y. C. Tseng, H. Y. Yang, W. T. Lin, C. B. Chang, H. C. Chien, H. P. Wang, et al. NPJ Biofilms Microbiomes 2021 Vol. 7 Issue 1 Pages 21 
Week 14
 5/18  Neoplastic disease – Oral cancer
Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma. D. W. 6Zheng, W. W. Deng, W. F. Song, C. C. Wu, J. Liu, S. Hong, et al. Nat Biomed Eng 2022 Vol. 6 Issue 1 Pages 32-43 
Week 15
 5/25  Neoplastic disease – Oral cancer
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1alpha co-activator driving oral cancer progression. J. W. Shih, W. F. Chiang, A. T. H. Wu, M. H. Wu, L. Y. Wang, Y. L. Yu, et al. Nat Commun 2017 Vol. 8 Pages 15874 
Week 16
 6/1  Final Exam Week